EndoBarrier Gastrointestinal Liner Delineation of underlying mechanisms and clinical effects
نویسندگان
چکیده
The thesis is based on these four original papers 1. Rohde U, Hedbäck N, Gluud LL, Vilsbøll T, Knop FK: Effect of the EndoBarrier Gastrointestinal Liner on obesity and type 2 diabetes: protocol for systematic review and meta-analysis of clinical studies. BMJ Open 2013; 3: e003417. (Study I) 2. Rohde U, Hedbäck N, Gluud LL, Vilsbøll T, Knop FK. Effect of the EndoBarrier Gastrointestinal Liner on obesity and type 2 diabetes: a systematic review and meta-analysis. Diabetes, Obesity and Metabolism 2016; 18: 300-5. (Study II) 3. Rohde U, Federspiel CA, Vilmann P, Langholz E, Friis SU, Krakauer M, Rehfeld JF, Holst JJ, Vilsbøll T, Knop FK. The Impact of EndoBarrier Gastrointestinal Liner in Obese Patients with Normal Glucose Tolerance and Patients with Type 2 Diabetes. Manuscript accepted for publication September 2016 in Diabetes, Obesity and Metabolism. (Study III) 4. Rohde U, Sonne DP, Christensen M, Hansen M, Brønden A, Toräng S, Rehfeld JF, Holst JJ, Vilsbøll T, Knop FK. Cholecystokinin-Induced Gallbladder Emptying and Single-Dose Metformin Elicit Additive Glucagon-Like Peptide-1 Responses. The Journal of Clinical Endocrinology and Metabolism 2016; 101: 2076–2083. (Study IV)
منابع مشابه
EndoBarrier gastrointestinal liner. Delineation of underlying mechanisms and clinical effects.
Bariatric surgery (e.g. Roux-en-Y gastric bypass (RYGB)) has proven the most effective way of achieving sustainable weight losses and remission of type 2 diabetes (T2D). Studies indicate that the effectiveness of RYGB is mediated by an altered gastrointestinal tract anatomy, which in particular favours release of the gut incretin hormone glucagon-like peptide-1 (GLP-1). The EndoBarrier gastroin...
متن کاملEffect of the EndoBarrier Gastrointestinal Liner on obesity and type 2 diabetes: protocol for systematic review and meta-analysis of clinical studies
INTRODUCTION Obese patients with type 2 diabetes undergoing bariatric surgery experience significant and lasting weight loss and improved glycaemic control. However, bariatric surgical procedures such as Roux-en-Y gastric bypass are irreversible and associated with considerable short-term and long-term risks. The EndoBarrier Gastrointestinal Liner or duodenal-jejunal bypass sleeve (DJBS) is a f...
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BACKGROUND Surgical intervention is now the most effective modality with which to treat severe obesity. There is currently a lack of minimally invasive technology with which we can effectively treat obesity and reverse type 2 diabetes mellitus. The EndoBarrier is a fluoropolymer sleeve that is reversibly fixated to the duodenal bulb and extends 80 cm into the small bowel, usually terminating in...
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In order to establish less invasive therapies for treatment of excess bodyweight and obesity, a device that is placed endoscopically has been developed that mimics some of the anatomical and enteroendocrine effects of bariatric surgery. The EndoBarrier system (GI Dynamics, Lexington, Massachusetts, USA) is a duodenal–jejunal bypass liner (DJBL) that consists of a 60-cm long, impermeable fluorop...
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